Design of Caspase Inhibitors as Potential Clinical Agents

by ;
Edition: 1st
Format: Hardcover
Pub. Date: 2008-10-28
Publisher(s): CRC Press
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Summary

Caspases represent one of the most specific protease families described to date. As caspase family members are involved in pro-inflammatory responses, inhibition of caspase activity represents a novel yet core approach to disease treatment. Design of Caspase Inhibitors as Potential Clinical Agentsdiscusses the role of cysteine aspartyl proteases (caspases) in inducing cell death. It reviews recent efforts to develop small molecular inhibitors that are capable of modulating caspase activity. The text also examines the difficulties encountered in transitioning small molecular inhibitors from the lab to clinical use, and discusses how these challenges can best be overcome to allow continued progress.

Table of Contents

Prefacep. vii
Editorsp. ix
Contributorsp. xi
Mammalian Caspase Activation Pathways in Apoptosis and Inflammationp. 1
Role of Caspases in Inflammation-Driven Diseasesp. 19
Role of Caspases in Apoptotic-Driven Indicationsp. 59
Kinetics and Catalytic Activity of Caspasesp. 75
Nonpeptide Small Molecule Inhibitors of Caspasesp. 93
Identification of Inflammatory Caspase Inhibitorsp. 123
Identification of Apoptotic Caspase Inhibitorsp. 161
Discovery of a First-in-Class Apoptotic Caspase Inhibitor Emricasan (PF-03491390/IDN-6556)p. 211
Novel Approaches to Caspase Inhibitor Discoveryp. 225
Therapeutic Potential for Caspase Inhibitors: Present and Futurep. 251
Indexp. 289
Table of Contents provided by Ingram. All Rights Reserved.

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