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From Spontaneous to Induced Neurological Mutations: A Personal Witness of the Ascent of the Mouse Model |
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1 | (20) |
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1 | (2) |
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Beginning: The Values and Limits of Spontaneous Mutations |
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3 | (6) |
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Renaissance: New Opportunities and Induced Mutations |
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9 | (5) |
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14 | (7) |
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15 | (6) |
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Mapping Genes that Modulate Mouse Brain Development: A Quantitative Genetic Approach |
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21 | (30) |
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21 | (1) |
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Why Brain Weight and Neuron Number Matter |
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22 | (2) |
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22 | (1) |
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22 | (1) |
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Insights into CNS Development |
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23 | (1) |
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Biometric Analysis of the Size and Structure of the Mouse CNS |
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24 | (3) |
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24 | (1) |
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24 | (1) |
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Brain Weight is Highly Variable |
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25 | (1) |
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Sex and Age Effects on Brain Weight |
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25 | (2) |
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Large Differences Between Substrains |
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27 | (1) |
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Mapping Brain Weight QTLs |
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27 | (12) |
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QTLs Versus Mendelian Loci |
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27 | (1) |
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Assessing Trait Variation |
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27 | (2) |
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29 | (1) |
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Phenotyping and Genotyping Members of an Experimental Cross |
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30 | (1) |
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Phenotyping and Regression Analysis |
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31 | (2) |
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33 | (1) |
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The Statistics of Mapping QTLs |
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34 | (2) |
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36 | (2) |
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38 | (1) |
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38 | (1) |
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Neuron and Glial Cell Numbers in Adult Mice |
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39 | (3) |
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The Mouse Brain Library at http://nervenet.org/mbl/mbl/html |
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40 | (1) |
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Numbers of Neurons and Glial Cells in the Brain of a Mouse |
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41 | (1) |
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Mapping QTLs that Modulate Neuron Number |
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42 | (2) |
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Mapping Cell-Specific QTLs |
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42 | (1) |
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42 | (1) |
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43 | (1) |
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43 | (1) |
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44 | (7) |
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44 | (7) |
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Genetic Interactions During Hindbrain Segmentation in the Mouse Embryo |
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51 | (40) |
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51 | (4) |
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Generation of Diversity in the Developing Nervous System |
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51 | (2) |
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Segmental Organisation of the Hindbrain |
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53 | (2) |
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Patterns of Gene Expression During Hindbrain Development |
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55 | (6) |
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55 | (3) |
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Upstream Regulators of Hox Genes |
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58 | (1) |
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59 | (2) |
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Genetic Control of Hindbrain Patterning |
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61 | (8) |
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62 | (2) |
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64 | (2) |
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66 | (1) |
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Hox Gene Auto- and Cross-Regulation |
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67 | (2) |
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Mutational Analyses of Gene Function |
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69 | (7) |
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69 | (3) |
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72 | (4) |
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Mechanisms of Hindbrain Segmentation |
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76 | (1) |
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77 | (14) |
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78 | (13) |
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Neurogenetic Compartments of the Mouse Diencephalon and some Characteristic Gene Expression Patterns |
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91 | (16) |
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91 | (3) |
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Origin and Definition of Diencephalon |
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94 | (2) |
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Diencephalic Segmentation |
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96 | (2) |
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Diencephalic Histogenetic Differentiation |
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98 | (1) |
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Alar Plate Domains at E12.5 |
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99 | (8) |
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103 | (4) |
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Neuronogenesis and the Early Events of the Neocortical Histogenesis |
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107 | (38) |
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107 | (2) |
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The Neocortical Pseudostratified Ventricular Epithelium |
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109 | (2) |
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Cytologic and Architectonic Features of the PVE |
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109 | (2) |
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Neocortex as Outcome of Neuronogenesis in the PVE |
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111 | (4) |
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The Radial Dimension of the Neocortex |
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113 | (1) |
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The Tangential Dimensions of the Neocortex |
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114 | (1) |
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The Proliferative Process Within the Murine Neocortical PVE |
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115 | (10) |
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There are Two Stages of Proliferative Activity in the PVE (Fig. 2) |
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116 | (1) |
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Neuron Production Advances in an Orderly Sequence |
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116 | (1) |
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The Proliferative State of PVE Varies Across the Surface of the Neocortex |
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117 | (1) |
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The Cell Cycle in Histogenesis |
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117 | (1) |
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A General Quantitative Model of Neuron Production |
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118 | (3) |
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Parameters of the Model: Experiments in Mouse |
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121 | |
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The Number of Integer Cycles |
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119 | (2) |
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121 | (2) |
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123 | (2) |
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Higher Order Neuronogenetic Control |
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125 | (6) |
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Number of Cell Cycles Regulated by Q |
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126 | (1) |
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Propagation of the Neuronogenetic Sequence Regulated by Tc |
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126 | (1) |
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Propagation of Cell Cycle Domains |
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127 | (1) |
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Initiation of Cycle at Origin |
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127 | (2) |
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Propagation of Cycle Domains |
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129 | (2) |
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The Proliferative Process and Histogenetic Specification |
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131 | (5) |
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Cell Number, Cell Class and Laminar Fate |
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131 | (3) |
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Regional Specification Within the PVE |
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134 | (2) |
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The PVE: A Conserved Histogenetic Specification |
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136 | (9) |
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138 | (7) |
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Programmed Cell Death in Mouse Brain Development |
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145 | (18) |
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145 | (1) |
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Conceptual Framework of Programmed Cell Death |
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145 | (2) |
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Mechanistic Framework of Programmed Cell Death |
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147 | (1) |
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Caspases-3 and -9 are Required for Developmental Apoptosis of Neurons |
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148 | (3) |
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The Bcl-2 Proteins Family Has Both Proapoptotic and Antiapoptotic Effects |
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151 | (3) |
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Apoptotic Defects in Founders and Postmitotic Neurons Have Distinct Consequences |
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154 | (2) |
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c-Jun N-Terminal Kinases Regulate Brain Region-Specific Apoptosis |
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156 | (2) |
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158 | (5) |
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160 | (3) |
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Neurotrophic Factors: Versatile Signals for Cell-Cell Communication in the Nervous System |
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163 | (26) |
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163 | (1) |
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The Neurotrophic Hypothesis |
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164 | (3) |
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167 | (1) |
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Beyond the Neurotrophic Hypothesis |
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168 | (3) |
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Revisiting the Neurotrophic Hypothesis with Molecular Genetics. |
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171 | (2) |
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Selective Neuronal Losses and Maturation Deficits Following Inactivation of Genes Encoding Neurotrophic Factors or Their Receptors |
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173 | (5) |
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Neurotrophic Factors Regulate Target Invasion |
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178 | (3) |
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BDNF as a Maturation Factor for the Cerebal Cortex |
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181 | (3) |
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184 | (5) |
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184 | (5) |
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Growth Factor Influences on the Production and Migration of Cortical Neurons |
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189 | (28) |
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189 | (1) |
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Trophic Factor Influences on Neurogenesis in the Ventricular Zone |
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190 | (6) |
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190 | (1) |
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Fibroblast Growth Factors |
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191 | (3) |
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Insulin-Like Growth Factors |
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194 | (1) |
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195 | (1) |
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Trophic Factor Influences on Glial-Guided Radial Migration |
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196 | (1) |
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Trophic Factor Influences on Tangential Migration |
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197 | (3) |
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NT4 Produces Heterotopic Accumulations of Neurons in the MZ in vitro |
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198 | (1) |
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NT4, But not BDNF, Produces Heterotopias in a TrkB-Mediated Response |
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198 | (2) |
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NT4 Also Produces Heterotopic Neuronal Collections in vivo |
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200 | (1) |
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Pathogenesis of NT4-Induced Heterotopias |
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200 | (4) |
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NT4 Does Not Induce Cell Proliferation in the Marginal Zone |
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201 | (1) |
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NT4-Induced Heterotopias are Composed of Marginal Zone Neurons |
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202 | (1) |
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NT4-Induced Accumulation of Neurons is not at the Expense of the Subplate |
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202 | (1) |
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Heterotopic Neurons are not Misplaced Cortical Plate Cells |
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202 | (1) |
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Heterotopias do not Result from the Trauma of Intraventricular Injection |
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203 | (1) |
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Heterotopias are not Caused by Rescue of MZ Neurons from Cell Death |
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203 | (1) |
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What is the Source of the Excess Neurons that Form NT4-Induced Heterotopias? |
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204 | (13) |
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207 | (10) |
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Signalling from Tyrosine Kinases in the Developing Neurons and Glia of the Mammalian Brain |
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217 | (24) |
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217 | (1) |
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Tyrosine Kinases During CNS Development |
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218 | (3) |
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Growth Factors and Their Cell Surface Receptors |
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218 | (3) |
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Phospho-Tyrosines and Their SH2 Partners |
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221 | (2) |
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Controlling the Activity of the Ras-MAPK Pathway |
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223 | (4) |
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223 | (2) |
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MAPK: Proliferation or Differentiation? |
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225 | (1) |
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Changing Adaptors for the Ras-MAPK Pathway: The Shc(s) |
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226 | (1) |
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Controlling Cell-Survival Via PI3K |
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227 | (2) |
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The JAK/STAT Pathway: A New Route to Proliferation and Differentiation in the Brain |
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229 | (3) |
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The Action of Phosphatases |
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232 | (1) |
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233 | (8) |
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234 | (7) |
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The Role of the p35/cdk5 Kinase in Cortical Development |
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241 | (14) |
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241 | (1) |
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241 | (1) |
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242 | (1) |
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243 | (1) |
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Function of the cdk5 Kinase in Neurite Outgrowth |
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243 | (1) |
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p35 and cdk5 Knockout Mice |
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244 | (3) |
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p35/cdk5 and Reeler/Scrambler |
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247 | (1) |
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248 | (1) |
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248 | (1) |
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249 | (6) |
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251 | (4) |
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The Reelin-Signaling Pathway and Mouse Cortical Development |
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255 | (22) |
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Catherine Lambert de Rouvroit |
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255 | (1) |
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Overview of Early Cortical Development in Normal Mice |
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255 | (3) |
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257 | (1) |
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Appearance of the Cortical Plate |
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257 | (1) |
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Cortical Phenotype in Reeler Mutant Mice |
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258 | (4) |
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262 | (6) |
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262 | (3) |
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Reln mRNA Expression During Cortical Development |
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265 | (1) |
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265 | (1) |
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266 | (1) |
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Reelin is Processed in vivo by a Metalloproteinase |
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266 | (1) |
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267 | (1) |
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Mouse Disabled1 and Scrambler/Yotari Mutations |
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268 | (3) |
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Very Low Density Lipoprotein Receptor and Apolipoprote in E Receptor Type 2 |
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271 | (6) |
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274 | (3) |
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The Subpial Granular Layer in the Developing Cerebral Cortex of Rodents |
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277 | (16) |
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277 | (2) |
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Neuronal Populations of the Rodent Marginal Zone |
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279 | (6) |
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279 | (2) |
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The Subpial Granular Layer |
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281 | (3) |
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Reelin-Expressing Cajal-Retzius Cells of Rodent Cortex |
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284 | (1) |
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Possible Origin of the Rodent Subpial Granular Layer |
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285 | (1) |
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Radial and Tangential Migration Pathways into the Cortex |
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286 | (2) |
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288 | (5) |
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289 | (4) |
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Development of Thalamocortical Projections in Normal and Mutant Mice |
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293 | (40) |
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293 | (1) |
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Neurogenesis and Formation of Mammalian Cortical Plate |
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294 | (1) |
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Introduction to Development of Thalamic Nuclei |
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295 | (1) |
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Overview of Thalamocortical Projections in the Adult Mouse |
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296 | (1) |
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Timing and Early Pattern of Thalamic Axon Outgrowth |
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296 | (5) |
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298 | (1) |
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Invasion of the Cortex and Establishment of Laminar Termination Patterns |
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299 | (2) |
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The Thalamocortical Pathways are Modified in Regions Where Transient Cells are Located During Development |
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301 | (1) |
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301 | (1) |
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Introduction to the Development of Barrel Cortex |
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302 | (2) |
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Mutant Mice Provide New Insights into Developmental Mechanisms |
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303 | (1) |
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Axonal Pathfinding at the Cortico-Striatal Junction in Tbr-1, Gbx-2 and Pax-6 KO Mice |
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304 | (6) |
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305 | (1) |
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305 | (1) |
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The reeler Mutant Mouse as a Model System to Explore Mechanisms of Thalamocortical Development |
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305 | (4) |
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309 | (1) |
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Possible Inhibitory Factory in and Around the Internal Capsule |
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309 | (1) |
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Mutants with Disturbances in Thalamocortical Interactions |
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310 | (12) |
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Barrel Formation in reeler Mouse |
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312 | (1) |
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313 | (1) |
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313 | (1) |
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Lack of Formation and Stabilisation of Barrel Patterns in the Mutant |
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314 | (1) |
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Similar Areal Differences in Thalamocortical Innervation Patterns in Normal and Barrelless Mice |
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314 | (1) |
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315 | (1) |
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The NMDA Receptor KO Mouse: Role of Activity in Barrel Formation |
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316 | (1) |
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A Specific Postsynaptic Defect in Barrel Formation Identified in PLC-$1 Knockout mice |
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317 | (1) |
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318 | (1) |
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Overview of Mutant Mice with Barrelless Phenotypes |
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319 | (1) |
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Mutations Indirectly Affecting Thalamocortical Development |
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319 | (1) |
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Thalamocortical Topography in Anophthalmic Mutants and After Early Binocular Enucleation |
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320 | (1) |
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Altered Thalamocortical Topography in Albinism and After Early Monocular Enucleation |
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321 | (1) |
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322 | (1) |
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322 | (11) |
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323 | (10) |
| Subject Index |
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333 | |
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