Sodium-Calcium Exchange and the Plasma Membrane Ca2+-ATPase in Cell Function Fifth International Conference, Volume 1099
by Herchuelz, Andre; Blaustein, Mordecai P.; Lytton, Jonathan; Philipson, Kenneth D.Edition: 1st
Format: Paperback
Pub. Date: 2007-04-23
Publisher(s): Wiley-Blackwell
Other versions by this Author
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Summary
Ca2+ homeostasis and the plasma membrane Na+/Ca2+ exchanger are vital to many cellular functions and physiological processes. This volume, which is the proceedings of the fifth in a series of international conferences, includes contributions that merge molecular biology, biochemistry, biophysics, and physiology, providing novel insights that significantly advance our understanding of Na+/Ca2+ exchanger in areas ranging from molecular mechanisms to the involvement in human disease.Several important themes are addressed: (1) structure-function relationships of the exchanger; (2) regulation of the exchanger; (3) Na/Ca exchanger gene regulation; (4) cellular location and targeting of the exchanger; (5) NC(K)X and PMCA KO mice; (6) Na/Ca exchanger interactions with other proteins; (7) Na/Ca exchange in cardiac function; (8) Na/Ca exchange in neuronal function; (9) Ca2+-extruding mechanisms and apoptosis; (10) Na/Ca exchange in smooth muscle, kidney, and endocrine function; (11) Na/Ca exchange inhibitors: therapeutic opportunities. Experts in the field of the plasma membrane Ca2+-ATPase (PMCA) have also contributed.The rate of progress in this field has been rapidly increasing, and new concepts have emerged regarding the relation between molecular structure and physiological function. New ideas on physiological modes of regulation have been increasingly testable through the use of transgenic animal models.This volume and the conference that preceded it continue the tradition of sharing information to fuel new advances in this exciting and important area of research.NOTE: Annals volumes are available for sale as individual books or as a journal. For information on institutional journal subscriptions, please visit www.blackwellpublishing.com/nyas.ACADEMY MEMBERS: Please contact the New York Academy of Sciences directly to place your order (www.nyas.org). Members of the New York Academy of Science receive full-text access to the Annals online and discounts on print volumes. Please visit www.nyas.org/membership/main.asp for more information about becoming a member.
Author Biography
Andre Herchuelz and Mordecai P. Blaustein are the authors of Sodium-Calcium Exchange and the Plasma Membrane Ca2+-ATPase in Cell Function: Fifth International Conference, Volume 1099, published by Wiley.
Table of Contents
| Historical note regarding the discovery of the Na/Ca exchanger and the PMCA | |
| What we know about the structure of NCX1 and how it relates to its function | p. 1 |
| Structural basis for Ca[superscript 2+] regulation in the Na[superscript +]/Ca[superscript 2+] exchanger | p. 7 |
| Structure-function relationships of the NCKX2 Na[superscript +]/Ca[superscript 2+]-K[superscript +] exchanger | p. 16 |
| Examining Ca[superscript 2+] extrusion of Na[superscript +]/Ca[superscript 2+]-K[superscript +] exchangers | p. 29 |
| Topologic investigation of the NCKX2 Na[superscript +]/Ca[superscript 2+]-K[superscript +] exchanger [alpha]-repeats | p. 34 |
| Transmembrane segments I, II, and VI of the canine cardiac Na[superscript +]/Ca[superscript 2+] exchanger are in proximity | p. 40 |
| Effect of Ca[superscript 2+] on protein kinase a-mediated phosphorylation of a specific serine residue in an expressed peptide containing the Ca[superscript 2+]-regulatory domain of scallop muscle Na[superscript +]/Ca[superscript 2+] exchanger | p. 43 |
| Regulation of the cardiac Na[superscript +]/Ca[superscript 2+] exchanger by calcineurin and protein kinase C | p. 53 |
| New modes of exchanger regulation : physiological implications | p. 64 |
| Shedding light on the Na[superscript +]/Ca[superscript 2+] exchanger | p. 78 |
| The regulation of the Na/Ca exchanger and plasmalemmal Ca[superscript 2+] ATPase by other proteins | p. 86 |
| Phosphorylation and other conundrums of Na/Ca exchanger, NCX1 | p. 103 |
| Regulation of cardiac Na[superscript +]/Ca[superscript 2+] exchanger by phospholemman | p. 119 |
| The squid preparation as a general model for ionic and metabolic Na[superscript +]/Ca[superscript 2+] exchange interactions : physiopathological implications | p. 135 |
| Some biochemical properties of the upregulation of the squid nerve Na[superscript +]/Ca[superscript 2+] exchanger by MgATP and phosphoarginine | p. 152 |
| Ionic selectivity of NCKX2, NCKX3, and NCKX4 for monovalent cations at K[superscript +] - binding site | p. 166 |
| In bovine heart Na[superscript +]/Ca[superscript 2+] exchanger maximal Ca[superscript 2+][subscript i] affinity requires simultaneously high pH[subscript i] and PtdIns-4,5-P2 binding to the carrier | p. 171 |
| NCX current in the murine embryonic heart : development-dependent regulation by Na[superscript +] | p. 175 |
| Gender differences in Na/Ca exchanger current and [beta]-adrenergic responsiveness in heart failure in pig myocytes | p. 183 |
| Roles of NCX and PMCA in basolateral calcium export associated with mineralization cycles and cold acclimation in crayfish | p. 190 |
| Modulation pathways of NCX mRNA stability : involvement of RhoB | p. 193 |
| Regulation of Ncxl gene expression in the normal and hypertrophic heart | p. 195 |
| Cyclosporin a-dependent downregulation of the Na[superscript +]/Ca[superscript 2+] exchanger expression | p. 204 |
| Functional significance of Na[superscript +]/Ca[superscript 2+] exchangers co-localization with ryanodine receptors | p. 215 |
| Three types of muscles express three sodium-calcium exchanger isoforms | p. 221 |
| Plasma membrane Ca[superscript 2+] ATPases as dynamic regulators of cellular calcium handling | p. 226 |
| Functional specificity of PMCA isoforms? | p. 237 |
| Plasma membrane calcium ATPase and its relationship to nitric oxide signaling in the heart | p. 247 |
| Functional importance of PMCA isoforms in growth and development of PC 12 cells | p. 254 |
| Na[superscript +]/Ca[superscript 2+] exchanger knockout mice : plasticity of cardiac excitation-contraction coupling | p. 270 |
| Distinct phenotypes among plasma membrane Ca[superscript 2+]-ATPase knockout mice | p. 276 |
| Role of plasma membrane calcium ATPase isoform 2 in neuronal function in the cerebellum and spinal cord | p. 287 |
| Increased tolerance to ischemic neuronal damage by knockdown of Na[superscript +]-Ca[superscript 2+] exchanger isoform 1 | p. 292 |
| Resistance of cardiac cells to NCX knockout : a model study | p. 306 |
| Homozygous overexpression of the Na[superscript +]-Ca[superscript 2+] exchanger in mice : evidence for increased transsarcolemmal Ca[superscript 2+] fluxes | p. 310 |
| Na/Ca exchange : regulator of intracellular calcium and source of arrhythmias in the heart | p. 315 |
| Na : Ca stoichiometry and cytosolic Ca-dependent activation of NCX in intact cardiomyocytes | p. 326 |
| Na/Ca exchange and cardiac ventricular arrhythmias | p. 339 |
| The role of the cardiac Na[superscript +]/Ca[superscript 2+] exchanger in reverse remodeling : relevance for LVAD-recovery | p. 349 |
| Regulation of Na[superscript +]/Ca[superscript 2+] exchange current in the normal and failing heart | p. 361 |
| Phosphorylation of Na[superscript +]/Ca[superscript 2+] exchanger in TAB-induced cardiac hypertrophy | p. 373 |
| Role of Ca[superscript 2+] transporters and channels in the cardiac cell volume regulation | p. 377 |
| NCX and NCKX operation in ischemic neurons | p. 383 |
| Na[superscript +]/Ca[superscript 2+] exchange and Ca[superscript 2+] homeostasis in axon terminals of mammalian central neurons | p. 396 |
| ncxl, ncx2, and ncx3 gene product expression and function in neuronal anoxia and brain ischemia | p. 413 |
| Sodium-calcium exchanger in pulmonary artery smooth muscle cells | p. 427 |
| Rapid downregulation of NCX and PMCA in hippocampal neurons following H[subscript 2]O[subscript 2] oxidative stress | p. 436 |
| Cleavage of the plasma membrane Ca[superscript 2+]ATPase during apoptosis | p. 440 |
| The plasma membrane Na[superscript +]/Ca[superscript 2+] exchanger is cleaved by distinct protease families in neuronal cell death | p. 451 |
| Role of Na/Ca exchange and the plasma membrane Ca[superscript 2+]-ATPase in [beta] cell function and death | p. 456 |
| Overexpression of Na/Ca exchanger reduces viability and proliferation of gliosarcoma cells | p. 468 |
| Redox modulation of the apoptogenic activity of thapsigargin | p. 469 |
| The role of Na[superscript +]/Ca[superscript +] exchanger in endothelin-1-aggravated hypoxia/reoxygenation-induced injury in renal epithelial cells | p. 473 |
| Involvement of Na[superscript +]/Ca[superscript 2+] exchanger type-1 in ischemia-induced neovascularization in the mouse hindlimb | p. 478 |
| The Na[superscript +]/Ca[superscript 2+] exchanger isoform 3 (NCX3) but not isoform 2 (NCX2) and 1 (NCX1) singly transfected in BHK cells plays a protective role in a model of in vitro hypoxia | p. 481 |
| Involvement of the potassium-dependent sodium/calcium exchanger gene product NCKX2 in the brain insult induced by permanent focal cerebral ischemia | p. 486 |
| Analysis of calcium changes in endoplasmic reticulum during apoptosis by the fluorescent indicator chlortetracycline | p. 490 |
| Sodium-calcium exchangers in the nucleus : an unexpected locus and an unusual regulatory mechanism | p. 494 |
| Mitochondrial Ca[superscript 2+] flux through Na[superscript +]/Ca[superscript 2+] exchange | p. 507 |
| Non-apoptogenic Ca[superscript 2+]-related extrusion of mitochondria in anoxia/ reoxygenation stress | p. 512 |
| Na[superscript +]/Ca[superscript 2+] exchange as a drug target - insights from molecular pharmacology and genetic engineering | p. 516 |
| Inhibitory mechanism of SN-6, a novel benzyloxyphenyl Na[superscript +]/Ca[superscript 2+] exchange inhibitor | p. 529 |
| Electrophysiological effects of SN-6, a novel Na[superscript +]/Ca[superscript 2+] exchange inhibitor on membrane currents in guinea pig ventricular myocytes | p. 534 |
| Directionality in drug action on sodium-calcium exchange | p. 540 |
| Table of Contents provided by Blackwell. All Rights Reserved. |
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